TY - JOUR T1 - The effect of clonidine TT - بررسی تأثیر کونیدین خوراکی به عنوان پیش داروی بیهوشی بر میزان اضطراب تغییرات علائم حیاتی و ایجادآرامش در بیماران کاندید بیهوشی عمومی در یکی از بیمارستانهای وابسته به دانشگاه علوم پزشکی ایران در سال 1372 JF - IJN JO - IJN VL - 12 IS - 18 UR - http://ijn.iums.ac.ir/article-1-1396-en.html Y1 - 1998 SP - 64 EP - 69 N2 -   The effect of clonidine, a central alpha2-adrenoreceptor agonist on reduction of anxiety, producing sedation and attenuation hemodynamic changes, were assessed during thissemi-experimental study in one of the hospitals of Iran medical sciences university in Tehran, 1994.   Fifty surgical patients of either sex, 18-60 years of age, with ASA physical status I or II, gave informed consent to enter this study.   At the preoperative visit on the evening before surgery, arterial blood pressure and heart rate were recorded and patient's anxiety were assessed by a scale (check list). Then patients were randomly assigned to either a clonidine (No=25) or control (No =25) group. In the study group, each patient received one tablet of clonidine (0.2 mg) 2-3 hours prior to coming to the operating room, and patients in control group, did not receive any medication.   On the patient's arrival in the operating room, the degree of sedation was assessed by researcher on a three point scale: awake and allert -drowsy but communicative -drowsy, uncommunicative. A second scale for anxiety was completed and heart rate and arterial blood pressure were recorded again anesthesia was induced intravenously with 3-5 mg/kg of tiopental-Na and 1.5 mg/kg succynil cholin to facilitate the laryngoscopy and tracheal intubation. Heart rate and arterial blood pressure were recoreded just before induction of anesthesia and one minute after tracheal intubation.   Results of this study are presented in 25 tables, and statistical analysis done by T -test, paired T-test and chi-square, statistical significance was accepted at P M3 ER -